Nanopathology : a new vision of the interaction environment-human life
نویسنده
چکیده
This article takes into consideration a new field of research called Nanopathology and describes the fundamentals of this new discipline. The paper is divided into three main sections: the in-vitro and in-vivo experiments with 5 types of nanoparticles, and the clinical pieces of evidence of the presence of particulate matter in human pathological tissues affected by diseases of unknown origin. The in-vitro experiments verified the interaction of 5 different types of nanoparticles with endothelial, gut and liver epithelial cells and macrophages from a toxicological and immunological point of view. The in-vivo experiments carried out on rats investigated the response to the implantation of 5 materials as nanoscaled particles and bulk disks in rats’ dorsal muscles. The clinical investigations verified the presence of inorganic micro and nano-particles in pathological tissues affected by cancer in different organs, leukaemia and lymphoma. The main in-vitro results indicated that: ain the presence of metallic nanoparticles (Cobalt), macrophages become unable to mount appropriate defence to bacterial challenge and danger exists of increased susceptibility to infections; bthe in-vivo tests indicated that metallic nanoparticles (and not the bulk samples) induced rhabdomyosarcoma in rats in 6 months; cthe clinical samples showed the constant presence of micro and nanoparticles in the tissues with variable chemistry, sometimes directly related to the working place exposure. Indications of new directions of the research are discussed.
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